KIT (gene)

KIT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH
Identifiers
Aliases	KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
External IDs	OMIM: 164920; MGI: 96677; HomoloGene: 187; GeneCards: KIT; OMA:KIT - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	54,740,715 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	75,817,382 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; secondary oocyte; ; skin of thigh; ; epithelium of lactiferous gland; ; gonad; ; lactiferous duct; ; cardia; ; parotid gland; ; skin of hip; ; visceral pleura;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; secondary oocyte; ; primary oocyte; ; zygote; ; gastrula; ; dermis; ; liver parenchyma; ; muscle layer of urethra; ; decidua;
	More reference expression data
	n/a
Gene ontology
Molecular function	stem cell factor receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; cytokine binding; protein kinase activity; metal ion binding; transferase activity; protein homodimerization activity; protease binding; protein binding; protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity; SH2 domain binding;
Cellular component	cytoplasm; membrane; cell-cell junction; cytoplasmic side of plasma membrane; cell surface; integral component of membrane; acrosomal vesicle; external side of plasma membrane; mast cell granule; extracellular space; plasma membrane; integral component of plasma membrane; receptor complex;
Biological process	melanocyte migration; myeloid progenitor cell differentiation; positive regulation of MAP kinase activity; glycosphingolipid metabolic process; positive regulation of phospholipase C activity; hematopoietic stem cell migration; stem cell population maintenance; protein phosphorylation; T cell differentiation; spermatogenesis; cell chemotaxis; developmental pigmentation; melanocyte differentiation; positive regulation of Notch signaling pathway; lamellipodium assembly; cytokine-mediated signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; melanocyte adhesion; lymphoid progenitor cell differentiation; spermatid development; erythrocyte differentiation; negative regulation of programmed cell death; protein autophosphorylation; mast cell degranulation; inflammatory response; positive regulation of MAPK cascade; myeloid leukocyte differentiation; male gonad development; phosphorylation; positive regulation of DNA-binding transcription factor activity; epithelial cell proliferation; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell shape; ovarian follicle development; ectopic germ cell programmed cell death; pigmentation; Fc receptor signaling pathway; response to radiation; mast cell cytokine production; positive regulation of receptor signaling pathway via JAK-STAT; dendritic cell cytokine production; visual learning; actin cytoskeleton reorganization; megakaryocyte development; intracellular signal transduction; somatic stem cell population maintenance; erythropoietin-mediated signaling pathway; Kit signaling pathway; positive regulation of cell migration; somatic stem cell division; mast cell chemotaxis; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pseudopodium assembly; positive regulation of gene expression; positive regulation of long-term neuronal synaptic plasticity; regulation of cell population proliferation; cellular response to thyroid hormone stimulus; positive regulation of cell population proliferation; embryonic hemopoiesis; regulation of developmental pigmentation; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; mast cell differentiation; digestive tract development; immature B cell differentiation; germ cell migration; signal transduction; mast cell proliferation; positive regulation of vascular associated smooth muscle cell differentiation; phosphatidylinositol phosphate biosynthetic process; regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; tongue development; response to cadmium ion; positive regulation of pyloric antrum smooth muscle contraction; regulation of bile acid metabolic process; positive regulation of small intestine smooth muscle contraction; positive regulation of colon smooth muscle contraction; positive regulation of protein kinase B signaling; hemopoiesis; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; B cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3815
	16590
	ENSG00000157404
	ENSMUSG00000005672
	P10721
	P05532
	NM_000222; NM_001093772
	NM_001122733; NM_021099
	NP_000213; NP_001087241
	NP_001116205; NP_066922
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit.