The 2022 Blood & Guts was the second annual Blood & Guts professional wrestling television special produced by All Elite Wrestling (AEW). It was held on June 29, 2022, at Little Caesars Arena in Detroit, Michigan. The event aired as a special episode of AEW's primary weekly television program, Wednesday Night Dynamite, which aired live on TBS. The July 1 episode of Friday Night Rampage on TNT, which was a special episode titled Royal Rampage and was the inaugural Royal Rampage, was also taped the same night immediately after the live broadcast of Blood & Guts.