bZIP domain

This article is about the protein domain. For the compression algorithm, see Bzip2.
bZIP transcription factor
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Identifiers
SymbolbZIP_1
PfamPF00170
InterProIPR011616
PROSITEPDOC00036
SCOP21ysa / SCOPe / SUPFAM
CDDcd14686
Membranome235
Available protein structures:
PDB  IPR011616 PF00170 (ECOD; PDBsum)  
AlphaFold

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.

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