BIBP-3226

BIBP-3226
Clinical data
Other names	BIBP-3226
Identifiers
	IUPAC name (2R)-5-(diaminomethylideneamino)-2-([2,2-diphenylacetyl]amino)-N-[(4-hydroxyphenyl)methyl]pentanamide;
CAS Number	159013-54-4 ;
PubChem CID	5311023;
IUPHAR/BPS	1485;
ChemSpider	4470561 ;
UNII	RG9766UGZ8;
ChEMBL	ChEMBL332347 ;
CompTox Dashboard (EPA)	DTXSID30415502 ;
Chemical and physical data
Formula	C27H31N5O3
Molar mass	473.577 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O;
	InChI InChI=1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)/t23-/m1/s1 ; Key:KUWBXRGRMQZCSS-HSZRJFAPSA-N ;
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BIBP-3226 is a drug used in scientific research which acts as a potent and selective antagonist for both the Neuropeptide Y receptor Y₁ and also the neuropeptide FF receptor. It was the first non-peptide antagonist developed for the Y₁ receptor and has been widely used to help determine its functions in the body. Activation of Y₁ is thought to be involved in functions such as regulation of appetite and anxiety, and BIBP-3226 has anxiogenic and anorectic effects, as well as blocking the Y₁-mediated corticotropin releasing hormone release. It has also been used as a lead compound to develop a number of newer more potent Y₁ antagonists.