BHLHE41

BHLHE41
Identifiers
Aliases	BHLHE41, DEC2, SHARP1, BHLHe41, HDEC2, SHARP-1, BHLHB3, Basic Helix-Loop-Helix Family Member E41, Basic Helix-Loop-Helix Family, Member E41, Class E Basic Helix-Loop-Helix Protein 41, Class B Basic Helix-Loop-Helix Protein 3, Basic Helix-Loop-Helix Domain Containing, Class B, 3, Differentially Expressed In Chondrocytes 2, Differentially Expressed In Chondrocytes Protein 2, Enhancer-Of-Split And Hairy-Related Protein 1, FNSS1
External IDs	OMIM: 606200; MGI: 1930704; HomoloGene: 137401; GeneCards: BHLHE41; OMA:BHLHE41 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	26,125,037 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	145,811,284 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; inferior ganglion of vagus nerve; ; Achilles tendon; ; optic nerve; ; subthalamic nucleus; ; spinal cord; ; C1 segment; ; corpus callosum; ; pars reticulata; ; external globus pallidus;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; zygote; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; skeletal muscle tissue; ; interventricular septum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; protein homodimerization activity; MRF binding; transcription corepressor activity; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; rhythmic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; negative regulation of myotube differentiation; animal organ morphogenesis; cell population proliferation; negative regulation of transcription, DNA-templated; circadian rhythm; somitogenesis; Notch signaling pathway; regulation of neurogenesis; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	79365
	79362
	ENSG00000123095
	ENSMUSG00000030256
	Q9C0J9
	Q99PV5
	NM_030762
	NM_001271768; NM_024469
	NP_110389
	NP_001258697; NP_077789
	Wikidata
View/Edit Human	View/Edit Mouse

"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.