BCR (gene)

Available protein structures:
PDB	IPR015123 PF09036 (ECOD; PDBsum)
AlphaFold	IPR015123; PF09036;

Bcr-Abl oncoprotein oligomerisation domain
Bcr-Abl oncoprotein oligomerisation domain
	structure of the bcr-abl oncoprotein oligomerization domain
Identifiers
Symbol	Bcr-Abl_Oligo
Pfam	PF09036
InterPro	IPR015123
PDB
Available protein structures:
PDB	IPR015123 PF09036 (ECOD; PDBsum)
AlphaFold	IPR015123; PF09036;

BCR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K1F, 2AIN
Identifiers
Aliases	BCR, Bcr, 5133400C09Rik, AI561783, AI853148, mKIAA3017, ALL, BCR1, CML, D22S11, D22S662, PHL, RhoGEF and GTPase activating protein, BCR gene, BCR activator of RhoGEF and GTPase
External IDs	OMIM: 151410; MGI: 88141; HomoloGene: 3192; GeneCards: BCR; OMA:BCR - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,318,037 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,020,753 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; putamen; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; sural nerve; ; right frontal lobe; ; prefrontal cortex; ; amygdala; ; right lobe of thyroid gland;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; superior frontal gyrus; ; globus pallidus; ; visual cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; neural layer of retina; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; guanyl-nucleotide exchange factor activity; kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; protein tyrosine kinase activity; ATP binding; GTPase activator activity;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; membrane; postsynaptic density; plasma membrane; synapse; cell junction; extracellular exosome; protein-containing complex; Schaffer collateral - CA1 synapse; glutamatergic synapse; postsynaptic density, intracellular component; intracellular anatomical structure;
Biological process	positive regulation of phagocytosis; intracellular signal transduction; neuromuscular process controlling balance; phosphorylation; regulation of cell cycle; negative regulation of blood vessel remodeling; protein phosphorylation; negative regulation of cellular extravasation; response to lipopolysaccharide; brain development; regulation of vascular permeability; negative regulation of cell migration; negative regulation of neutrophil degranulation; inner ear morphogenesis; protein autophosphorylation; platelet-derived growth factor receptor signaling pathway; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; negative regulation of inflammatory response; actin cytoskeleton organization; signal transduction; peptidyl-tyrosine phosphorylation; renal system process; homeostasis of number of cells; regulation of nitrogen compound metabolic process; definitive hemopoiesis; negative regulation of respiratory burst; intracellular protein transmembrane transport; cellular response to lipopolysaccharide; negative regulation of reactive oxygen species metabolic process; positive regulation of GTPase activity; modulation of chemical synaptic transmission; small GTPase mediated signal transduction; keratinocyte differentiation; focal adhesion assembly; activation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	613
	110279
	ENSG00000186716
	ENSMUSG00000009681
	P11274
	Q6PAJ1
	NM_004327; NM_021574
	NM_001081412
	NP_004318; NP_067585
	NP_001074881
	Wikidata
View/Edit Human	View/Edit Mouse

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.