BAR domain

BAR domain
Structure of amphiphysin BAR.
Identifiers
SymbolBAR
PfamPF03114
InterProIPR004148
SMARTSM00721
PROSITEPDOC51021
SCOP21uru / SCOPe / SUPFAM
CDDcd07307
Available protein structures:
PDB  IPR004148 PF03114 (ECOD; PDBsum)  
AlphaFold
Bin/amphiphysin/Rvs domain
Identifiers
SymbolBAR-2
PfamPF10455
Available protein structures:
PDB  PF10455 (ECOD; PDBsum)  
AlphaFold
BAR domain of APPL family
Identifiers
SymbolBAR-3
PfamPF16746
Available protein structures:
PDB  PF16746 (ECOD; PDBsum)  
AlphaFold
EFC/F-BAR homology domain
Identifiers
SymbolFCH
PfamPF00611
Available protein structures:
PDB  PF00611 (ECOD; PDBsum)  
AlphaFold
Vps5 C terminal like (BAR domain)
Identifiers
SymbolVps5
PfamPF09325
InterProIPR015404
Available protein structures:
PDB  IPR015404 PF09325 (ECOD; PDBsum)  
AlphaFold
WASP-binding domain of sorting nexin proteins
Identifiers
SymbolBAR-3-WASP
PfamPF10456
Available protein structures:
PDB  PF10456 (ECOD; PDBsum)  
AlphaFold

In molecular biology, BAR domains are highly conserved protein dimerisation domains that occur in many proteins involved in membrane dynamics in a cell. The BAR domain is banana-shaped and binds to membrane via its concave face. It is capable of sensing membrane curvature by binding preferentially to curved membranes. BAR domains are named after three proteins that they are found in: Bin, Amphiphysin and Rvs.

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