Bcl-2-associated death promoter

Available protein structures:
PDB	IPR018868 PF10514 (ECOD; PDBsum)
AlphaFold	IPR018868; PF10514;

Pro-apoptotic Bcl-2 protein, BAD
Pro-apoptotic Bcl-2 protein, BAD
	complex of bcl-xl with peptide from bad
Identifiers
Symbol	Bcl-2_BAD
Pfam	PF10514
InterPro	IPR018868
PDB
Available protein structures:
PDB	IPR018868 PF10514 (ECOD; PDBsum)
AlphaFold	IPR018868; PF10514;

BAD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G5J
Identifiers
Aliases	BAD, BBC2, BCL2L8, BCL2 associated agonist of cell death
External IDs	OMIM: 603167; MGI: 1096330; HomoloGene: 3189; GeneCards: BAD; OMA:BAD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,284,704 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,929,267 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right frontal lobe; ; right auricle of heart; ; apex of heart; ; body of stomach; ; C1 segment; ; olfactory zone of nasal mucosa; ; right coronary artery; ; muscle layer of sigmoid colon; ; left coronary artery;
	Top expressed in
	blastocyst; ; internal carotid artery; ; external carotid artery; ; lip; ; facial motor nucleus; ; duodenum; ; right kidney; ; pyloric antrum; ; granulocyte; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	14-3-3 protein binding; protein phosphatase binding; protein binding; protein heterodimerization activity; cysteine-type endopeptidase activator activity involved in apoptotic process; phospholipid binding; protein kinase binding; lipid binding; protein phosphatase 2B binding; protein kinase B binding;
Cellular component	cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion;
Biological process	positive regulation of T cell differentiation; cellular response to hypoxia; regulation of apoptotic process; response to amino acid; response to estradiol; response to hypoxia; positive regulation of type B pancreatic cell development; response to organic cyclic compound; extrinsic apoptotic signaling pathway; positive regulation of autophagy; glucose homeostasis; cytokine-mediated signaling pathway; response to testosterone; positive regulation of epithelial cell proliferation; positive regulation of B cell differentiation; response to progesterone; positive regulation of apoptotic process by virus; pore complex assembly; cellular response to nicotine; response to glucocorticoid; positive regulation of neuron death; response to glucose; regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to organic substance; response to calcium ion; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ATP metabolic process; cellular response to mechanical stimulus; activation of cysteine-type endopeptidase activity; regulation of mitochondrial membrane permeability; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of glucokinase activity; spermatogenesis; glucose catabolic process; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of proteolysis; cerebral cortex development; extrinsic apoptotic signaling pathway in absence of ligand; cellular response to lipid; positive regulation of release of cytochrome c from mitochondria; response to hormone; positive regulation of mitochondrial membrane potential; positive regulation of insulin secretion involved in cellular response to glucose stimulus; suppression by virus of host apoptotic process; response to ethanol; ADP metabolic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; cell population proliferation; type B pancreatic cell proliferation; cellular response to chromate; extrinsic apoptotic signaling pathway via death domain receptors; response to hydrogen peroxide; response to oleic acid; release of cytochrome c from mitochondria; positive regulation of insulin secretion; apoptotic process; intrinsic apoptotic signaling pathway; apoptotic signaling pathway; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of apoptotic process; positive regulation of granulosa cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	572
	12015
	ENSG00000002330
	ENSMUSG00000024959
	Q92934
	Q61337
	NM_032989; NM_004322
	NM_007522; NM_001285453
	NP_004313; NP_116784
	NP_001272382; NP_031548
	Wikidata
View/Edit Human	View/Edit Mouse

The BCL2 associated agonist of cell death (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAD is a member of the BH3-only family, a subfamily of the Bcl-2 family. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family. After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis.