Autosomal dominant leukodystrophy with autonomic disease
| Autosomal dominant leukodystrophy with autonomic disease | |
|---|---|
| Other names | Autosomal dominant adult-onset demyelinating leukodystrophy, ADLD, Adult-onset autosomal dominant demyelinating leukodystrophy, Adult-onset autosomal dominant leukodystrophy, Leukodystrophy, demyelinating, adult-onset, autosomal dominant, Pelizaeus-Merzbacher disease, autosomal dominant or late-onset type, Multiple sclerosis-like disorder |
| Specialty | Medical genetics |
| Symptoms | Cognitive deficits, ataxia, and dysfunctions of the autonomic system |
| Complications | Walking difficulties |
| Usual onset | Adulthood |
| Duration | Lifelong |
| Causes | Genetic mutation |
| Diagnostic method | Genetic testing |
| Differential diagnosis | Multiple sclerosis |
| Prevention | none |
| Prognosis | Bad, but quality of life can be improved with treatment |
| Frequency | rare, at least 70 people on Earth have been diagnosed with the condition |
| Deaths | Inevitable in patients with this condition |
Autosomal dominant leukodystrophy with autonomic disease is a rare neurological condition of genetic origin which is characterized by gradual demyelination of the central nervous system which results in various impairments, including ataxia, mild cognitive disability and autonomic dysfunction. It is part of a group of disorders called "leukodystrophies".