Arsenic trioxide

Arsenic trioxide
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.014.075
35185
KEGG
  • InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3
    Key: KTTMEOWBIWLMSE-UHFFFAOYSA-N
  • O1[As]2O[As]3O[As]1O[As](O2)O3
Properties
As4O6
Molar mass 395.680 g·mol−1
Appearance white solid
Density 3.74 g/cm3
Melting point 312.2 °C (594.0 °F; 585.3 K)
Boiling point 465 °C (869 °F; 738 K)
20 g/L (25 °C (77 °F; 298 K))
Hazards
GHS labelling:
Danger
H300, H314, H350, H410
P201, P202, P260, P264, P270, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340+P310, P305+P351+P338+P310, P308+P313, P363, P391, P405, P501
0.05 mg/m3 (TWA)
NIOSH (US health exposure limits):
PEL (Permissible)
0.010 mg/m3 (TWA, as As)
REL (Recommended)
0.002 mg/m3 (15 minute, as As)
IDLH (Immediate danger)
5 mg/m3 (as As)
Safety data sheet (SDS) Safety Data Sheet
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Arsenic trioxide is the inorganic compound with the formula As4O6. As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass. For medical purposes, it is sold under the brand name Trisenox among others when used as a medication to treat a type of cancer known as acute promyelocytic leukemia. For this use it is given by injection into a vein.

Arsenic trioxide was approved for medical use in the United States in 2000. It is on the World Health Organization's List of Essential Medicines. Approximately 50,000 tonnes were produced in 1991. Due to its toxicity, a number of countries have regulations around its manufacture and sale.