Arfaptin
| Arfaptin | |||||||
|---|---|---|---|---|---|---|---|
crystal structure analysis of rac1-gdp complexed with arfaptin (p21) | |||||||
| Identifiers | |||||||
| Symbol | Arfaptin | ||||||
| Pfam | PF06456 | ||||||
| Pfam clan | CL0145 | ||||||
| InterPro | IPR010504 | ||||||
| SCOP2 | 1i4l / SCOPe / SUPFAM | ||||||
| CDD | cd00011 | ||||||
| |||||||
In molecular biology, the arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.