Arbaclofen placarbil

Arbaclofen placarbil
Clinical data
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Development terminated;
Identifiers
	IUPAC name (3R)-3-(4-chlorophenyl)-4-[[[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid;
CAS Number	847353-30-4;
PubChem CID	11281011;
ChemSpider	9456008;
UNII	W89H91R7VX;
KEGG	D08861 ;
ChEMBL	ChEMBL2107312 ;
CompTox Dashboard (EPA)	DTXSID40233754 ;
ECHA InfoCard	100.221.150
Chemical and physical data
Formula	C19H26ClNO6
Molar mass	399.87 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C(=O)O[C@@H](OC(=O)NC[C@H](CC(=O)O)c1ccc(Cl)cc1)C(C)C;
	InChI InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1; Key:JXTAALBWJQJLGN-KSSFIOAISA-N;

Arbaclofen placarbil (/ɑːrˈbækloʊfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.

It is being developed as an addiction medicine to treat alcoholism. It is also studied as a potential therapy for some autistic subjects.