Angiogenin

ANG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A4Y, 1ANG, 1AWZ, 1B1E, 1B1I, 1B1J, 1GV7, 1H0D, 1H52, 1H53, 1HBY, 1K58, 1K59, 1K5A, 1K5B, 1UN3, 1UN4, 1UN5, 2ANG, 4AHD, 4AHE, 4AHF, 4AHG, 4AHH, 4AHI, 4AHJ, 4AHK, 4AHL, 4AHM, 4AHN, 4AOH, 4B36
Identifiers
Aliases	ANG, ALS9, HEL168, RAA1, RNASE4, RNASE5, angiogenin, ribonuclease, RNase A family, 5, angiogenin
External IDs	OMIM: 105850; MGI: 88022; HomoloGene: 74385; GeneCards: ANG; OMA:ANG - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,698,971 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,339,466 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left ovary; ; right ovary; ; rectum; ; body of stomach; ; canal of the cervix; ; gastric mucosa; ; Descending thoracic aorta; ; olfactory zone of nasal mucosa; ; right lung;
	Top expressed in
	left lobe of liver; ; epithelium of stomach; ; islet of Langerhans; ; Paneth cell; ; gallbladder; ; migratory enteric neural crest cell; ; lumbar spinal ganglion; ; ileum; ; ankle; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; rRNA binding; heparin binding; protein homodimerization activity; peptide binding; protein binding; nucleic acid binding; nuclease activity; endonuclease activity; actin binding; copper ion binding; signaling receptor binding; hydrolase activity; ribonuclease activity;
Cellular component	extracellular region; nucleolus; angiogenin-PRI complex; cytoplasmic vesicle; nucleus; extracellular space; growth cone; soma; basement membrane;
Biological process	cell differentiation; negative regulation of smooth muscle cell proliferation; negative regulation of translation; activation of protein kinase B activity; response to hypoxia; positive regulation of endothelial cell proliferation; placenta development; rRNA transcription; activation of phospholipase C activity; activation of phospholipase A2 activity; diacylglycerol biosynthetic process; multicellular organism development; cell communication; actin filament polymerization; oocyte maturation; angiogenesis; positive regulation of protein secretion; ovarian follicle development; response to hormone; positive regulation of phosphorylation; adherens junction organization; cell migration; homeostatic process; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis; innate immune response; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	283
	11727
	ENSG00000214274
	ENSMUSG00000072115
	P03950
	P21570
	NM_001145; NM_001097577
	NM_001161731; NM_007447
	NP_001091046; NP_001136
	NP_001155203; NP_031473
	Wikidata
View/Edit Human	View/Edit Mouse

Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA. Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.