Alice Chien Chang

Alice Chien Chang
錢嘉韻
Born
Chien Chia-yun

(1950-03-14)March 14, 1950
Taiwan
DiedMarch 2, 2026(2026-03-02) (aged 75)
Taipei, Taiwan
CitizenshipTaiwanese
Alma materFu Jen Catholic University
University of Cincinnati
Iowa State University
Scientific career
FieldsMolecular biology, Neuroscience
InstitutionsEast Carolina University
National Yang-Ming Medical College
National Yang-Ming University
National Yang Ming Chiao Tung University
Academic advisorsHorst Dieter Dellmann

Alice Chien Chang (March 14, 1950 – March 2, 2026) was a Taiwanese molecular biologist and neuroscientist. She taught at National Yang-Ming Medical College, National Yang-Ming University, and National Yang Ming Chiao Tung University. In 1976, she and her collaborators published research on the purification of a DNA polymerase from the extreme thermophile Thermus aquaticus; this work was later regarded as one of the key technical foundations that enabled the high-temperature cycling, automation, and commercialization of the polymerase chain reaction (PCR).