Advanced glycation end-product

Advanced glycation end-products (AGEs) are proteins or lipids that become glycated after exposure to sugars. They are formed through a series of non-enzymatic reactions explained in further detail below, and their accumulation is associated with a variety of metabolic diseases such as diabetes, atherosclerosis, chronic kidney disease, age-related macular degeneration (even in non-diabetic animals), and Alzheimer's disease.