Holo-(acyl-carrier-protein) synthase
| phosphopantetheinyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
holo-[acyl-carrier-protein] synthase trimer, Helicobacter pylori | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.8.7 | ||||||||
| CAS no. | 37278-30-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| ACPS | |||||||
|---|---|---|---|---|---|---|---|
crystal structure of the 4'-phosphopantetheinyl transferase sfp-coenzyme a complex | |||||||
| Identifiers | |||||||
| Symbol | ACPS | ||||||
| Pfam | PF01648 | ||||||
| InterPro | IPR008278 | ||||||
| SCOP2 | 1qr0 / SCOPe / SUPFAM | ||||||
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In enzymology and molecular biology, a holo-[acyl-carrier-protein] synthase (ACPS, EC 2.7.8.7) is an enzyme that catalyzes the chemical reaction:
- CoA-[4'-phosphopantetheine] + apo-acyl carrier protein adenosine 3',5'-bisphosphate + holo-acyl carrier protein
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups, and more specifically to the 4'-phosphopantetheinyl transferases (PPTases) named after the group they transfer.
In mammals, this activity is performed by the PPTase, aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT), which acts in both the cytosol and mitochondria and also modifies non-acyl carrier protein (ACP) substrates.