Acute zonal occult outer retinopathy

Acute Zonal Occult Outer Retinopathy (AZOOR) is a rare, presumed inflammatory retinopathy that involves the outer regions of the retina and is typically associated with visual field defects and visual disturbances known as photopsia. It was first characterized in 1992 by Gass and since then, has been categorized into a group of disorders called white dot syndromes. The disease served as a major plot point in the BBC drama Second Sight which aired from 2000 to 2001.

AZOOR is most commonly seen in young to middle-age adults with a female predominance of approximately 3:1. One systematic review found the median age of onset to be 35 years, however the condition may present anywhere between 12 to 85 years of age.