Acute eosinophilic leukemia

Acute eosinophilic leukemia
SpecialtyHematology, oncology

Acute eosinophilic leukemia (AEL) is a rare subtype of acute myeloid leukemia with characteristic tyrosine kinase (TK) gene fusions and sometimes eosinophilia. Prior to advances in molecular genetics, acute eosinophilic leukemia was described as a distinct subtype of acute non-lymphocytic leukemia with early eosinophilic differentiation and a marker positive for cyanide-resistant peroxidase stain. However, with advances in molecular genetics the current classification system characterizes AEL based on the most common gene rearrangements:

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