"ACHE" redirects here. For other uses, see
Ache.
| ACHE |
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| Identifiers |
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| Aliases | ACHE, AChE, acetylhydrolase, acetylcholinesterase (Yt blood group), ACEE, ARN-YT, acetylcholinesterase (Cartwright blood group), true cholinesterase (dated synonym) |
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| External IDs | OMIM: 100740; MGI: 87876; HomoloGene: 543; GeneCards: ACHE; OMA:ACHE - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 5 (mouse) |
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| | Band | 5 G2|5 76.32 cM | Start | 137,285,781 bp |
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| End | 137,292,728 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - muscle of thigh
- right hemisphere of cerebellum
- hypothalamus
- gastrocnemius muscle
- nucleus accumbens
- triceps brachii muscle
- Skeletal muscle tissue of rectus abdominis
- right frontal lobe
- putamen
- caudate nucleus
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| | Top expressed in | - medulla oblongata
- pons
- central gray substance of midbrain
- bone marrow
- superior colliculus
- hypothalamus
- cerebellar cortex
- striatum of neuraxis
- nucleus of stria terminalis
- inferior colliculi
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters:
- acetylcholine + H2O = choline + acetate
It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate cholinergic synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.