Aceclidine

Aceclidine
Clinical data
Other names	LNZ101
AHFS/Drugs.com	Vizz
License data	US DailyMed: Aceclidine;
Routes of; administration	Topical (ophthalmic solution)
ATC code	S01EB08 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-Azabicyclo[2.2.2]oct-3-yl acetate; 3-Quinuclidinyl Acetate;
CAS Number	827-61-2; 6109-70-2;
PubChem CID	1979;
ChemSpider	1902;
UNII	0578K3ELIO;
KEGG	D02750;
ChEMBL	ChEMBL20835;
CompTox Dashboard (EPA)	DTXSID2045658 ;
ECHA InfoCard	100.011.431
Chemical and physical data
Formula	C9H15NO2
Molar mass	169.224 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC2C1CCN(CC1)C2)C;
	InChI InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3; Key:WRJPSSPFHGNBMG-UHFFFAOYSA-N;

Aceclidine is a parasympathomimetic cholinergic drug that functions as a muscarinic acetylcholine receptor agonist. It is used in ophthalmology as a miotic agent to constrict the pupil. Historically used in Europe for the treatment of glaucoma, aceclidine received its first U.S. approval in 2025 under the brand name Vizz as a topical eye drop for the correction of presbyopia. Its mechanism of action produces pupil contraction with a relatively minimal effect on the ciliary muscle, which improves near visual acuity through a "pinhole" depth-of-field effect without inducing significant accommodative spasm.