Acetylserotonin O-methyltransferase

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acetylserotonin O-methyltransferase
acetylserotonin O-methyltransferase
Identifiers
EC no.	2.1.1.4
CAS no.	9029-77-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

ASMT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A6D, 4A6E
Identifiers
Aliases	ASMT, ASMTY, HIOMT, HIOMTY, acetylserotonin O-methyltransferase
External IDs	OMIM: 402500, 300015; MGI: 96090; HomoloGene: 48261; GeneCards: ASMT; OMA:ASMT - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	1,643,081 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	169,111,844 bp
RNA expression pattern
	Top expressed in
	testicle; ; anterior pituitary; ; oocyte; ; bone marrow; ; sural nerve; ; olfactory zone of nasal mucosa; ; canal of the cervix; ; ectocervix; ; left uterine tube; ; body of uterus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein homodimerization activity; O-methyltransferase activity; acetylserotonin O-methyltransferase activity; identical protein binding; S-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity;
Cellular component	cytosol;
Biological process	melatonin biosynthetic process; methylation; protein biosynthesis; indolalkylamine biosynthetic process; aromatic compound biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	438
	107626
	ENSG00000196433
	ENSMUSG00000093806
	P46597
	D3KU66
	NM_004043; NM_001171038; NM_001171039
	NM_001199212; NM_001308488
	NP_001164509; NP_001164510; NP_004034
	NP_001186141; NP_001295417
	Wikidata
View/Edit Human	View/Edit Mouse

N-Acetylserotonin O-methyltransferase, also known as ASMT, is an enzyme which catalyzes the final reaction in melatonin biosynthesis: converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate. The other enzyme which catalyzes this reaction is N-acetylserotonin-o-methyltransferase-like-protein.