ARHGEF7

ARHGEF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BY1, 1ZSG, 2L3G
Identifiers
Aliases	ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, Rho guanine nucleotide exchange factor 7
External IDs	OMIM: 605477; MGI: 1860493; HomoloGene: 2895; GeneCards: ARHGEF7; OMA:ARHGEF7 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	111,305,737 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	11,835,219 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; sural nerve; ; right hemisphere of cerebellum; ; tibial arteries; ; cerebellar vermis; ; skin of thigh; ; skin of hip; ; right coronary artery; ; subcutaneous adipose tissue; ; left coronary artery;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; genital tubercle; ; external carotid artery; ; internal carotid artery; ; barrel cortex; ; endocardial cushion; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo; ; ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; cell projection; focal adhesion; ruffle; plasma membrane; cell junction; soma; cell cortex; neuron projection; storage vacuole; lamellipodium; intracellular anatomical structure;
Biological process	regulation of GTP binding; intracellular signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of lamellipodium morphogenesis; Golgi organization; ephrin receptor signaling pathway; nervous system development; focal adhesion assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of growth hormone secretion; hematopoietic progenitor cell differentiation; positive regulation of apoptotic process; positive regulation of protein binding; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of fibroblast migration; signal transduction; lamellipodium assembly; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8874
	54126
	ENSG00000102606
	ENSMUSG00000031511
	Q14155
	Q9ES28
NM_001113511; NM_001113512; NM_001113513; NM_003899; NM_145735;
	NM_001320851; NM_001320852; NM_001320853; NM_001320854; NM_001330597; NM_001330598; NM_001354046; NM_001354047; NM_001354048; NM_001354049; NM_001354050; NM_001354051; NM_001354052; NM_001354053; NM_001354054; NM_001354055; NM_001354056; NM_001354057; NM_001354058; NM_001354059; NM_001354060; NM_001354061
NM_001113517; NM_001113518; NM_017402; NM_001372321; NM_001372322;
	NM_001372323; NM_001372324; NM_001372325; NM_001372326
NP_001106983; NP_001106984; NP_001106985; NP_001307780; NP_001307781;
	NP_001307782; NP_001307783; NP_001317526; NP_001317527; NP_003890; NP_663788; NP_001340975; NP_001340976; NP_001340977; NP_001340978; NP_001340979; NP_001340980; NP_001340981; NP_001340982; NP_001340983; NP_001340984; NP_001340985; NP_001340986; NP_001340987; NP_001340988; NP_001340989; NP_001340990; NP_001106985.1; NP_003890.1; NP_001307780.1
NP_001106989; NP_001106990; NP_059098; NP_001359250; NP_001359251;
	NP_001359252; NP_001359253; NP_001359254; NP_001359255
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

ARHGEF7 is commonly known as the p21-activated protein kinase exchange factor beta (beta-PIX or βPIX), because it was identified by binding to p21-activated kinase (PAK) and also contains a guanine nucleotide exchange factor domain.