ARHGEF2

ARHGEF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EFX
Identifiers
Aliases	ARHGEF2, GEF, GEF-H1, GEFH1, LFP40, P40, Rho/Rac guanine nucleotide exchange factor 2, NEDMHM, Lfc
External IDs	OMIM: 607560; MGI: 103264; HomoloGene: 3468; GeneCards: ARHGEF2; OMA:ARHGEF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,007,070 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,555,359 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; ganglionic eminence; ; corpus callosum; ; C1 segment; ; olfactory bulb; ; blood; ; granulocyte; ; sural nerve; ; upper lobe of left lung; ; right lung;
	Top expressed in
	spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; primary visual cortex; ; neural layer of retina; ; neural tube; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule binding; zinc ion binding; transcription factor binding; metal ion binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; vesicle; cytosol; Golgi apparatus; cell projection; membrane; focal adhesion; bicellular tight junction; spindle; plasma membrane; dendritic shaft; ruffle membrane; cell junction; soma; microtubule; cytoskeleton; cytoplasmic vesicle; podosome; postsynaptic density; protein-containing complex; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of necroptotic process; actin filament organization; immune system process; negative regulation of neurogenesis; cellular response to tumor necrosis factor; cell division; cellular response to muramyl dipeptide; cellular hyperosmotic response; negative regulation of microtubule depolymerization; regulation of cell population proliferation; positive regulation of NF-kappaB transcription factor activity; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; cell morphogenesis; establishment of mitotic spindle orientation; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; cell cycle; regulation of Rho protein signal transduction; intracellular protein transport; innate immune response; regulation of small GTPase mediated signal transduction; positive regulation of transcription by RNA polymerase II; negative regulation of podosome assembly; G protein-coupled receptor signaling pathway; positive regulation of neuron differentiation; asymmetric neuroblast division; positive regulation of neuron migration; multicellular organism development; nervous system development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	9181
	16800
	ENSG00000116584
	ENSMUSG00000028059
	Q92974
	Q60875
NM_001162383; NM_001162384; NM_004723; NM_001350110; NM_001350111;
	NM_001350112
	NM_001198911; NM_001198912; NM_001198913; NM_008487; NM_001377126
NP_001155855; NP_001155856; NP_004714; NP_001337039; NP_001337040;
	NP_001337041
	NP_001185840; NP_001185841; NP_001185842; NP_032513; NP_001364055
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.