ARAP1

ARAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4X1V
Identifiers
Aliases	ARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, cnt-d2
External IDs	OMIM: 606646; MGI: 1916960; HomoloGene: 12326; GeneCards: ARAP1; OMA:ARAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,793,599 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,061,793 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right uterine tube; ; upper lobe of left lung; ; right lung; ; spleen; ; right adrenal cortex; ; left adrenal cortex; ; anterior pituitary; ; right lobe of thyroid gland;
	Top expressed in
	granulocyte; ; lip; ; gastrula; ; stroma of bone marrow; ; efferent ductule; ; tibiofemoral joint; ; thymus; ; lumbar spinal ganglion; ; uterus; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; protein binding; GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding; type 1 angiotensin receptor binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; Golgi cisterna membrane; trans-Golgi network; cytoplasmic vesicle; nucleoplasm; cytosol; plasma membrane; intracellular membrane-bounded organelle;
Biological process	actin filament reorganization involved in cell cycle; regulation of cell shape; negative regulation of stress fiber assembly; regulation of small GTPase mediated signal transduction; positive regulation of filopodium assembly; signal transduction; positive regulation of receptor recycling; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	116985
	69710
	ENSG00000186635
	ENSMUSG00000032812
	Q96P48
	Q4LDD4
	NM_015242; NM_001040118; NM_001135190; NM_001369489
	NM_001040111; NM_001040112; NM_027180; NM_198096
	NP_001035207; NP_001128662; NP_056057; NP_001356418
NP_001035200; NP_001035201; NP_081456; NP_932764; NP_001394730;
	NP_001394732
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene. It regulates the endosomal pathway and cytoskeletal dynamics using its GTPase-activating protein activity.