ANTH domain
| ANTH domain | |||||||
|---|---|---|---|---|---|---|---|
Clathrin assembly lymphoid myeloid leukemia (CALM) protein | |||||||
| Identifiers | |||||||
| Symbol | ANTH | ||||||
| Pfam | PF07651 | ||||||
| InterPro | IPR011417 | ||||||
| OPM superfamily | 38 | ||||||
| OPM protein | 1hfa | ||||||
| CDD | cd03564 | ||||||
| |||||||
The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 (homologous to CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).
An ANTH domain is also found in HIP1 and HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved.