ANKH

ANKH
Identifiers
Aliases	ANKH, ANK, CCAL2, CMDJ, CPPDD, HANK, MANK, ANKH inorganic pyrophosphate transport regulator, SLC62A1
External IDs	OMIM: 605145; MGI: 3045421; HomoloGene: 10664; GeneCards: ANKH; OMA:ANKH - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	14,871,778 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	27,594,995 bp
RNA expression pattern
	Top expressed in
	tibia; ; parotid gland; ; inferior ganglion of vagus nerve; ; pons; ; right ventricle; ; Skeletal muscle tissue of biceps brachii; ; subthalamic nucleus; ; synovial joint; ; superior vestibular nucleus; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	seminal vesicula; ; right ventricle; ; digastric muscle; ; ankle; ; temporal muscle; ; lip; ; muscle of thigh; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphate ion transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; inorganic diphosphate transmembrane transporter activity;
Cellular component	membrane; outer membrane; integral component of membrane; integral component of plasma membrane; plasma membrane;
Biological process	skeletal system development; transmembrane transport; locomotory behavior; phosphate ion transport; phosphate ion transmembrane transport; regulation of bone mineralization; inorganic diphosphate transport;
	Sources:Amigo / QuickGO
Orthologs
	56172
	11732
	ENSG00000154122
	ENSMUSG00000022265
	Q9HCJ1
	Q9JHZ2
	NM_054027
	NM_020332
	NP_473368
	NP_065065
	Wikidata
View/Edit Human	View/Edit Mouse

Progressive ankylosis protein homolog (ANK ilosis H omolog) is a protein that in humans is encoded by the ANKH gene. ANKH is a multipass transmembrane protein that is expressed in joints and other tissues. It is involved in transport of pyrophosphate (an inhibitor of hydroxyapatite precipitation) from cells into the extracellular space. It is expressed in osteoblasts. Deficiencies of ANKH are associated with excessive calcification of bone and with metastatic calcification.