ALPI

ALPI
Identifiers
Aliases	ALPI, IAP, alkaline phosphatase, intestinal
External IDs	OMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,460,753 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,055,634 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; mucosa of ileum; ; mucosa of transverse colon; ; rectum; ; human kidney; ; muscle tissue; ; smooth muscle tissue; ; appendix; ; gallbladder;
	Top expressed in
	duodenum; ; embryo; ; jejunum; ; temporal muscle; ; upper arm; ; secretory cell; ; colon; ; triceps brachii muscle; ; mucous cell of stomach; ; midbrain tectum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protease binding; phosphatase activity; zinc ion binding; protein binding; catalytic activity; hydrolase activity; magnesium ion binding; metal ion binding; alkaline phosphatase activity;
Cellular component	integral component of membrane; anchored component of membrane; membrane; extracellular region; plasma membrane;
Biological process	metabolism; dephosphorylation; phosphatidic acid biosynthetic process; digestion;
	Sources:Amigo / QuickGO
Orthologs
	248
	11648
	ENSG00000163295
	ENSMUSG00000036500
	P09923
	P24822
	NM_001631
	NM_007432
	NP_001622
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene. Its chemical formula is:C₂₆₇₉H₄₁₉₆O₉₆₅N₆₇₂S₁₈P₂.

Intestinal alkaline phosphatase is an endogenous enzyme that maintains gut homeostasis. It detoxifyies bacterial toxins, dephosphorylates phosphorylated nucleotides, regulates lipid absorption in the intestine, and regulates the microbiome in the intestine. In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.