AKAP13

AKAP13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DRN, 2LG1, 4D0N, 4D0O
Identifiers
Aliases	AKAP13, A kinase (PRKA) anchor protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchoring protein 13, A-kinase anchor protein 13
External IDs	OMIM: 604686; MGI: 2676556; HomoloGene: 4903; GeneCards: AKAP13; OMA:AKAP13 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	85,749,358 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	75,754,609 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; Achilles tendon; ; lower lobe of lung; ; sural nerve; ; epithelium of colon; ; visceral pleura; ; pylorus; ; apex of heart; ; tail of epididymis; ; right ventricle;
	Top expressed in
	mesenteric lymph nodes; ; lumbar spinal ganglion; ; blood; ; submandibular gland; ; bone marrow; ; spleen; ; granulocyte; ; foot; ; extraocular muscle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; MAP-kinase scaffold activity; guanyl-nucleotide exchange factor activity; protein binding; molecular adaptor activity; protein kinase A binding; signal transducer activity; cAMP-dependent protein kinase activity;
Cellular component	membrane; cytosol; actin cytoskeleton; perinuclear region of cytoplasm; nucleus; cell cortex; actin filament; cortical actin cytoskeleton; cytoplasm; intracellular anatomical structure;
Biological process	regulation of cardiac muscle hypertrophy; bone development; intracellular signal transduction; regulation of glucocorticoid mediated signaling pathway; positive regulation of Rho protein signal transduction; regulation of sarcomere organization; positive regulation of I-kappaB kinase/NF-kappaB signaling; adrenergic receptor signaling pathway; regulation of small GTPase mediated signal transduction; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; development of the heart; positive regulation of apoptotic process; cardiac muscle cell differentiation; regulation of Rho protein signal transduction; protein phosphorylation; regulation of protein kinase activity; nuclear export; G protein-coupled receptor signaling pathway; positive regulation of MAP kinase activity; cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologs
	11214
	75547
	ENSG00000170776
	ENSMUSG00000066406
	Q12802
	E9Q394
	NM_144767; NM_001270546; NM_006738; NM_007200; NM_032162
	NM_029332
	NP_001257475; NP_006729; NP_009131
	NP_083608
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.