AIFM1

AIFM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M6I, 4BUR, 4BV6, 4FDC, 4LII, 5FS7, 5FS9, 5FS6, 5FS8
Identifiers
Aliases	AIFM1, AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, DFNX5, apoptosis inducing factor, mitochondria associated 1, apoptosis inducing factor mitochondria associated 1, AUNX1, SEMDHL
External IDs	OMIM: 300169; MGI: 1349419; HomoloGene: 3100; GeneCards: AIFM1; OMA:AIFM1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	130,165,879 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	47,602,440 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; human kidney; ; left ventricle; ; right adrenal cortex; ; mucosa of transverse colon; ; right lobe of liver; ; right auricle of heart; ; left adrenal gland; ; left adrenal cortex; ; myocardium of left ventricle;
	Top expressed in
	Ileal epithelium; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; choroid plexus; ; choroid plexus of fourth ventricle; ; Epithelium of choroid plexus; ; right kidney; ; human kidney; ; proximal tubule; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein dimerization activity; oxidoreductase activity; flavin adenine dinucleotide binding; NAD(P)H oxidase H2O2-forming activity; FAD binding; oxidoreductase activity, acting on NAD(P)H; DNA binding;
Cellular component	mitochondrial inner membrane; cytoplasm; cytosol; membrane; perinuclear region of cytoplasm; mitochondrial intermembrane space; mitochondrion; nucleus;
Biological process	neuron apoptotic process; response to ischemia; chromosome condensation; cellular response to oxygen-glucose deprivation; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of neuron apoptotic process; regulation of apoptotic DNA fragmentation; cellular response to hydrogen peroxide; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; cellular response to nitric oxide; response to L-glutamate; positive regulation of cell death; mitochondrial respiratory chain complex I assembly; response to toxic substance; cellular response to estradiol stimulus; neuron differentiation; cellular response to aldosterone; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9131
	26926
	ENSG00000156709
	ENSMUSG00000036932
	O95831
	Q9Z0X1
	NM_001130846; NM_001130847; NM_004208; NM_145812; NM_145813
	NM_001290364; NM_012019
	NP_001124318; NP_001124319; NP_004199; NP_665811
	NP_001277293; NP_036149
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptosis-inducing factor 1, mitochondrial is a protein that in humans is encoded by the AIFM1 gene on the X chromosome. This protein localizes to the mitochondria, as well as the nucleus, where it carries out nuclear fragmentation as part of caspase-independent apoptosis.