Actin, alpha skeletal muscle

ACTA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T44
Identifiers
Aliases	ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, Actin, alpha 1, SHPM, actin, alpha 1, skeletal muscle, actin alpha 1, skeletal muscle
External IDs	OMIM: 102610; MGI: 87902; HomoloGene: 121702; GeneCards: ACTA1; OMA:ACTA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	229,434,104 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	124,621,490 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; glutes; ; triceps brachii muscle; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; tibialis anterior muscle; ; muscle of thigh; ; gastrocnemius muscle; ; body of tongue; ; deltoid muscle;
	Top expressed in
	ankle; ; soleus muscle; ; plantaris muscle; ; medial head of gastrocnemius muscle; ; intercostal muscle; ; muscle of thigh; ; body of femur; ; digastric muscle; ; temporal muscle; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; myosin binding; ADP binding; structural constituent of cytoskeleton; protein binding; ATP binding;
Cellular component	cytoplasm; cell body; cytosol; blood microparticle; filopodium; sarcomere; striated muscle thin filament; stress fiber; extracellular fluid; actin filament; actin cytoskeleton; extracellular exosome; cytoskeleton; lamellipodium;
Biological process	muscle contraction; response to steroid hormone; skeletal muscle fiber adaptation; response to mechanical stimulus; skeletal muscle thin filament assembly; response to lithium ion; cell growth; positive regulation of gene expression; muscle filament sliding; mesenchyme migration; response to extracellular stimulus; skeletal muscle fiber development;
	Sources:Amigo / QuickGO
Orthologs
	58
	11459
	ENSG00000143632
	ENSMUSG00000031972
	P68133
	P68134
	NM_001100
	NM_001272041; NM_009606
	NP_001091
	NP_001258970; NP_033736
	Wikidata
View/Edit Human	View/Edit Mouse

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.