ACSF3

ACSF3
Identifiers
Aliases	ACSF3, acyl-CoA synthetase family member 3
External IDs	OMIM: 614245; MGI: 2182591; HomoloGene: 14958; GeneCards: ACSF3; OMA:ACSF3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,164,121 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	122,817,880 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; granulocyte; ; right adrenal gland; ; sural nerve; ; bone marrow cell; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; appendix;
	Top expressed in
	Ileal epithelium; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; right kidney; ; lactiferous gland; ; corneal stroma; ; brown adipose tissue; ; otic vesicle; ; proximal tubule; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; malonyl-CoA synthetase activity; ligase activity; ATP binding; catalytic activity; acid-thiol ligase activity; very long-chain fatty acid-CoA ligase activity; methylmalonyl-CoA synthetase activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	malonate catabolic process; metabolism; fatty acid biosynthetic process; long-chain fatty-acyl-CoA biosynthetic process; fatty acid metabolic process; lipid metabolism; protein malonylation;
	Sources:Amigo / QuickGO
Orthologs
	197322
	257633
	ENSG00000176715
	ENSMUSG00000015016
	Q4G176
	Q3URE1
	NM_001127214; NM_001243279; NM_001284316; NM_174917
	NM_144932
	NP_001120686; NP_001230208; NP_001271245; NP_777577
	NP_659181
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA synthetase family member 3 (ACSF3) is a mitochondrial enzyme encoded by the ACSF3 gene. It is required for the degradation of malonic acid and methylmalonic acid and provides the precursor for mitochondrial fatty acid synthesis (mtFAS) and mitochondrial lysine malonylation. The enzyme belongs to the acyl-CoA synthetase family.