ABCA1

ABCA1
Identifiers
Aliases	ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP1
External IDs	OMIM: 600046; MGI: 99607; HomoloGene: 21130; GeneCards: ABCA1; OMA:ABCA1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	104,928,155 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	53,159,895 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; skin of thigh; ; right adrenal cortex; ; epithelium of colon; ; stromal cell of endometrium; ; lower lobe of lung; ; liver;
	Top expressed in
	stroma of bone marrow; ; subcutaneous adipose tissue; ; skin of external ear; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; transitional epithelium of urinary bladder; ; gastrula; ; decidua; ; left lobe of liver; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ATPase-coupled transmembrane transporter activity; apolipoprotein binding; nucleotide binding; ATPase binding; apolipoprotein A-I receptor activity; anion transmembrane transporter activity; phospholipid transporter activity; cholesterol binding; small GTPase binding; protein binding; syntaxin binding; signaling receptor binding; phospholipid binding; ATP binding; cholesterol transfer activity; phosphatidylserine floppase activity; ATPase activity; phosphatidylcholine floppase activity; apolipoprotein A-I binding; high-density lipoprotein particle binding; lipid transporter activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; plasma membrane; endocytic vesicle; integral component of plasma membrane; cell surface; phagocytic vesicle; high-density lipoprotein particle; perinuclear region of cytoplasm; membrane raft; external side of plasma membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endosome;
Biological process	G protein-coupled receptor signaling pathway; cellular response to retinoic acid; phospholipid homeostasis; steroid metabolic process; platelet dense granule organization; regulation of Cdc42 protein signal transduction; response to nutrient; lipid metabolism; phospholipid efflux; phospholipid transport; cholesterol transport; response to laminar fluid shear stress; peptide secretion; cholesterol metabolic process; cellular response to cholesterol; negative regulation of cholesterol storage; endosomal transport; phagocytosis, engulfment; anion transmembrane transport; intracellular cholesterol transport; cholesterol efflux; protein lipidation; lipoprotein biosynthetic process; lysosome organization; cellular response to lipopolysaccharide; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport; apolipoprotein A-I-mediated signaling pathway; positive regulation of cholesterol efflux; phospholipid translocation; regulation of high-density lipoprotein particle assembly; transmembrane transport; cholesterol homeostasis; regulation of lipid metabolic process; high-density lipoprotein particle assembly; lipoprotein metabolic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to low-density lipoprotein particle stimulus; lipid transport; positive regulation of high-density lipoprotein particle assembly;
	Sources:Amigo / QuickGO
Orthologs
	19
	11303
	ENSG00000165029
	ENSMUSG00000015243
	O95477
	P41233
	NM_005502
	NM_013454
	NP_005493
	NP_038482
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.