8-OH-DPAT

8-OH-DPAT
Clinical data
Other names	8-Hydroxy-2-(dipropylamino)tetralin; 8-Hydroxy-2-(di-n-propylamino)tetralin
Drug class	Serotonin 5-HT1A receptor agonist; Serotonin 5-HT7 receptor agonist; Serotonin reuptake inhibitor or releasing agent
ATC code	None;
Identifiers
	IUPAC name 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;
CAS Number	78950-78-4 ;
PubChem CID	1220;
IUPHAR/BPS	7;
ChemSpider	1183 ;
UNII	IWS1724PX6;
ChEBI	CHEBI:73364 ;
ChEMBL	ChEMBL56 ;
CompTox Dashboard (EPA)	DTXSID30897384 ;
Chemical and physical data
Formula	C16H25NO
Molar mass	247.382 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CCC)C1CCc2cccc(O)c2C1;
	InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3 ; Key:ASXGJMSKWNBENU-UHFFFAOYSA-N ;
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8-OH-DPAT, also known as 8-hydroxy-2-(dipropylamino)tetralin, is a serotonin 5-HT_1A receptor agonist of the 2-aminotetralin family which was developed in the 1980s and has been widely used to study the function of the 5-HT_1A receptor. It was one of the first major 5-HT_1A receptor full agonists to have been discovered.

Originally believed to be selective for the 5-HT_1A receptor, 8-OH-DPAT was later found to act as a serotonin 5-HT₇ receptor agonist and serotonin reuptake inhibitor or releasing agent as well.

In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic (antiaggressive), anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.