5-IAI

5-IAI
Clinical data
Other names5-Iodo-2-aminoindane; 5-Iodo-2-aminoindan; 5-IAI; NRG-5
Routes of
administration
Oral
Drug classSerotonin–norepinephrine–dopamine releasing agent; Entactogen
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Duration of action2–4 hours
Identifiers
  • 5-iodo-2,3-dihydro-1H-inden-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H10IN
Molar mass259.090 g·mol−1
3D model (JSmol)
  • c2c1CC(N)Cc1ccc2I
  • InChI=1S/C9H10IN/c10-8-2-1-6-4-9(11)5-7(6)3-8/h1-3,9H,4-5,11H2 Y
  • Key:BIHPYCDDPGNWQO-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

5-Iodo-2-aminoindane (5-IAI) is an entactogen drug of the 2-aminoindane family. Human anecdotal reports suggest that it is entactogenic but produces little euphoria or stimulation.

The drug acts as a releasing agent of serotonin, norepinephrine, and dopamine. It produces much less serotonergic neurotoxicity than MDMA in animals.

5-IAI was developed in the 1990s by a team led by David E. Nichols at Purdue University. It was encountered as a novel recreational designer drug in 2010, but never gained widespread popularity.