5-HT_2A receptor

HTR2A
Identifiers
Aliases	HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
External IDs	OMIM: 182135; MGI: 109521; HomoloGene: 68073; GeneCards: HTR2A; OMA:HTR2A - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	46,897,076 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; middle temporal gyrus; ; frontal pole; ; Brodmann area 23; ; Brodmann area 10; ; Brodmann area 46; ; endothelial cell; ; orbitofrontal cortex; ; superior frontal gyrus; ; primary visual cortex;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G protein-coupled receptor activity; virus receptor activity; signal transducer activity; G-protein alpha-subunit binding; G protein-coupled serotonin receptor activity; serotonin binding; neurotransmitter receptor activity; protein binding; protein-containing complex binding;
Cellular component	cytoplasm; integral component of membrane; cytosol; cell projection; membrane; cell body fiber; integral component of plasma membrane; dendritic shaft; axon; soma; caveola; cytoplasmic vesicle; plasma membrane; dendrite; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	detection of mechanical stimulus involved in sensory perception of pain; release of sequestered calcium ion into cytosol; regulation of dopamine secretion; phospholipase C-activating serotonin receptor signaling pathway; urinary bladder smooth muscle contraction; positive regulation of MAP kinase activity; behavioral response to cocaine; positive regulation of cytosolic calcium ion concentration; positive regulation of kinase activity; positive regulation of phosphatidylinositol biosynthetic process; ageing; cellular calcium ion homeostasis; cell death; memory; activation of phospholipase C activity; detection of temperature stimulus involved in sensory perception of pain; protein localization to cytoskeleton; sleep; positive regulation of vasoconstriction; positive regulation of cell population proliferation; negative regulation of potassium ion transport; positive regulation of ERK1 and ERK2 cascade; artery smooth muscle contraction; positive regulation of peptidyl-tyrosine phosphorylation; viral entry into host cell; phosphatidylinositol 3-kinase signaling; sensory perception of pain; temperature homeostasis; viral process; positive regulation of fat cell differentiation; positive regulation of glycolytic process; negative regulation of synaptic transmission, glutamatergic; signal transduction; chemical synaptic transmission; serotonin receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; animal behavior; regulation of synaptic vesicle exocytosis; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
	Sources:Amigo / QuickGO
Orthologs
	3356
	15558
	ENSG00000102468
	ENSMUSG00000034997
	P28223
	P35363
	NM_001165947; NM_000621; NM_001378924
	NM_172812
	NP_000612; NP_001159419; NP_001365853
	NP_766400
	Wikidata
View/Edit Human	View/Edit Mouse

The 5-HT_2A receptor is a subtype of the 5-HT₂ receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades. Like all 5-HT₂ receptors, the 5-HT_2A receptor is coupled to the G_q/G₁₁ signaling pathway. It is the primary excitatory receptor subtype among the serotonin-responsive GPCRs. The 5-HT_2A receptor was initially noted for its central role as the primary target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. It later regained research prominence when found to mediate, at least in part, the effects of many antipsychotic drugs, particularly atypical antipsychotics.