Eutropoflavin

Eutropoflavin
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2-[4-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one;
CAS Number	1205548-04-4;
PubChem CID	44610701;
ChemSpider	26630138;
UNII	B2M862MR4W;
ChEMBL	ChEMBL1800922;
CompTox Dashboard (EPA)	DTXSID901045822 ;
Chemical and physical data
Formula	C17H15NO4
Molar mass	297.310 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O;
	InChI InChI=1S/C17H15NO4/c1-18(2)11-5-3-10(4-6-11)15-9-14(20)12-7-8-13(19)16(21)17(12)22-15/h3-9,19,21H,1-2H3; Key:YPAYCZOHGRSGJS-UHFFFAOYSA-N;

Eutropoflavin (4'-dimethylamino-7,8-dihydroxyflavone) is a synthetic flavone-type selective agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), which was derived from structural modification of tropoflavin (7,8-DHF). Relative to tropoflavin, eutropoflavin possesses higher agonistic activity at TrkB, is significantly more potent than tropoflavin both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and "partially decaying" at 8~16 hours in rodents). The compound has been found to produce neuroprotective and neurogenic effects in the brain and spinal cord as well as antidepressant-like effects in animals. It has been sold online as a nootropic.