2025 US Open – Wheelchair women's singles

Further information: 2025 US Open (tennis)

Wheelchair women's singles
2025 US Open
Champion Yui Kamiji
Runner-up Li Xiaohui
Score0–6, 6–1, 6–3
Draw16
Seeds4

Yui Kamiji defeated Li Xiaohui in the final, 0–6, 6–1, 6–3 to win the women's singles wheelchair tennis title at the 2025 US Open.

Diede de Groot was the six-time defending champion, but lost in the quarterfinals to Kamiji in a rematch of the past seven years' finals.

There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.

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