2025 US Open – Wheelchair women's doubles
| Wheelchair women's doubles | |
|---|---|
| 2025 US Open | |
| Champions | Li Xiaohui Wang Ziying |
| Runners-up | Diede de Groot Zhu Zhenzhen |
| Score | 6–4, 7–6(7–4) |
| Draw | 8 |
| Seeds | 2 |
Li Xiaohui and Wang Ziying defeated Diede de Groot and Zhu Zhenzhen in the final, 6–4, 7–6(7–4) to win the women's doubles wheelchair tennis title at the 2025 US Open.
Yui Kamiji and Kgothatso Montjane were the defending champions, but they lost in the semifinals to De Groot and Zhu.
There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.