2025 US Open – Wheelchair quad singles

Further information: 2025 US Open (tennis)

Wheelchair quad singles
2025 US Open
Champion Niels Vink
Runner-up Sam Schröder
Score7–5, 6–3
Draw16
Seeds4

Niels Vink defeated defending champion Sam Schröder in a rematch of the previous two years' finals, 7–5, 6–3 to win the quad singles wheelchair tennis title at the 2025 US Open.

There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.

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