2025 US Open – Wheelchair quad doubles
| Wheelchair quad doubles | |
|---|---|
| 2025 US Open | |
| Champions | Guy Sasson Niels Vink |
| Runners-up | Francisco Cayulef Gonzalo Enrique Lazarte |
| Score | 6–1, 6–1 |
| Draw | 8 |
| Seeds | 2 |
Three-time defending champion Niels Vink and his partner Guy Sasson defeated Francisco Cayulef and Gonzalo Enrique Lazarte in the final, 6–1, 6–1 to win the quad doubles wheelchair tennis title at the 2025 US Open.
Sam Schröder and Vink were the three-time defending champions, but chose not to compete together this year. Schröder partnered Ahmet Kaplan, but lost in the semifinals to Cayulef and Enrique Lazarte.
There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.