2025 US Open – Wheelchair men's singles

Further information: 2025 US Open (tennis)

Wheelchair men's singles
2025 US Open
Champion Tokito Oda
Runner-up Gustavo Fernández
Score6–2, 3–6, 7–6(13–11)
Draw16
Seeds4

Tokito Oda defeated Gustavo Fernández in the final, 6–2, 3–6, 7–6(13–11) to win the men's singles wheelchair tennis title at the 2025 US Open. It was his seventh major singles title, completing the career Grand Slam and career Golden Slam in men’s singles wheelchair tennis.

Alfie Hewett was the two-time defending champion, but lost in the semifinals to Fernández.

There was no edition of the event in 2024 due to a scheduling conflict with the 2024 Summer Paralympics.

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