2025 US Open – Men's doubles

Marcel Granollers and Horacio Zeballos defeated Joe Salisbury and Neal Skupski in the final, 3–6, 7–6^(7–4), 7–5 to win the men's doubles tennis title at the 2025 US Open. They saved three championship points en route to the title. It was the second major title for both players, following the 2025 French Open.

Max Purcell and Jordan Thompson were the reigning champions, but Purcell did not participate as he was serving a suspension for violating anti-doping rules. Thompson partnered Matthew Ebden, but lost in the first round to Karol Drzewiecki and Marcus Willis.

Lloyd Glasspool retained the ATP No. 1 doubles ranking after Marcelo Arévalo and Mate Pavić lost in the second round.

This tournament marked the final major appearances of five-time major doubles champion and former world No. 1 Nicolas Mahut, who partnered Giovanni Mpetshi Perricard; they lost in the first round to Kevin Krawietz and Tim Pütz, two-time major doubles champion and former world No. 1 Rohan Bopanna, who partnered Romain Arneodo; they lost in the first round to Robert Cash and JJ Tracy, and seven-time major doubles champion and Olympic silver medalist Ivan Dodig, who partnered Jamie Murray; they lost in the first round to Rafael Matos and Marcelo Melo.