2025 Palermo Ladies Open – Singles
| Singles | |
|---|---|
| 2025 Palermo Ladies Open | |
| Champion | Francesca Jones |
| Runner-up | Anouk Koevermans |
| Score | 6–3, 6–2 |
| Draw | 32 |
| Seeds | 8 |
Francesca Jones won the singles title at the 2025 Palermo Ladies Open, defeating Anouk Koevermans 6-3, 6–2 in the final. It was her second WTA 125 title and came just two weeks after her first at Contrexéville.
Zheng Qinwen was the two-time reigning champion, but did not participate this year.