2025 Los Cabos Open – Singles
| Singles | |
|---|---|
| 2025 Los Cabos Open | |
| Champion | Denis Shapovalov |
| Runner-up | Aleksandar Kovacevic |
| Score | 6–4, 6–2 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Denis Shapovalov defeated Aleksandar Kovacevic in the final, 6–4, 6–2 to win the singles tennis title at the 2025 Los Cabos Open. He did not lose a set en route to his fourth career ATP Tour title, and first outside of indoor hardcourts. Shapovalov and Kovacevic were the first pair of players with one-handed backhands to contest an ATP Tour final since Stefanos Tsitsipas and Dominic Thiem at the 2019 ATP Finals.
Jordan Thompson was the reigning champion, but withdrew before the tournament began.