2023 US Open – Men's singles

Novak Djokovic defeated Daniil Medvedev in the final, 6–3, 7–6^(7–5), 6–3 to win the men's singles tennis title at the 2023 US Open. It was his fourth US Open title and record-extending 24th men's singles major title overall. Djokovic became the second oldest US Open men's singles champion in the Open Era, at 36 years, 3 months and 19 days old. By reaching a 47th men's singles major semifinal, he surpassed Roger Federer's all-time record, and by reaching the final, he equaled Federer's record of reaching all four major finals in a season three times. The final was a rematch of the 2021 final, won by Medvedev. By winning his first-round match, Djokovic regained the world No. 1 singles ranking from Carlos Alcaraz.

Alcaraz was the defending champion, but lost in the semifinals to Medvedev.

This tournament marked the last US Open appearance of 2012 champion, three-time major champion, two-time Olympic gold medalist, and former world No. 1 Andy Murray; he lost in the second round to Grigor Dimitrov. Murray's first round win against Corentin Moutet was his 200th and final major win. It was also the final professional appearance of former world No. 8 and career-ace record-holder John Isner; he lost in the second round to Michael Mmoh.