2022 Tennis Napoli Cup – Singles

Singles
2022 Tennis Napoli Cup
Champion Lorenzo Musetti
Runner-up Matteo Berrettini
Score7–6(7–5), 6–2
Main article: 2022 Tennis Napoli Cup

Lorenzo Musetti defeated Matteo Berrettini in the final, 7–6(7–5), 6–2 to win the singles tennis title at the 2022 Napoli Cup. It was his second career ATP Tour singles title.

Tallon Griekspoor was the reigning champion from 2021, when the tournament was an ATP Challenger Tour event, but chose to compete in Antwerp instead.

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