2021–22 Spartan South Midlands Football League

The 2021–22 season was the 25th in the history of the Spartan South Midlands Football League, a football competition in England. The league operates three divisions, two of which are in covered in this article: the Premier Division at Step 5, and Division One at Step 6 of the English football league system.

The league constitution for this season was based on allocations for Steps 5 and 6 that were announced by The Football Association on 18 May 2021, and were subject to appeal.

After the abandonment of the 2019–20 and 2020–21 seasons due to the COVID-19 pandemic in England, numerous promotions were decided on a points per game basis over the previous two seasons.