2021–22 Cypriot Second Division
| Season | 2021–22 |
|---|---|
| Dates | 10 September 2021 – 14 May 2022 |
| Champions | Karmiotissa (2nd title) |
| Runner up | Nea Salamis Famagusta |
| Promoted | Karmiotissa Nea Salamis Famagusta Akritas Chlorakas Enosis Neon Paralimni |
| Relegated | ASIL Lysi |
| Matches | 240 |
| Goals | 614 (2.56 per match) |
| Top goalscorer | Ioannis Chatzivasilis (20 goals) |
| Biggest home win | Onisilos Sotira 6-0 Omonia Aradippou (20 November 2021) |
| Biggest away win | Alki Oroklini 0-6 Karmiotissa (14 May 2022) |
| Highest scoring | Achyronas Liopetriou 6-2 Ermis Aradippou (30 April 2022) |
| Longest unbeaten run | Karmiotissa (12 matches) |
| Longest winless run | Achyronas Liopetriou (11 matches) |
| Longest losing run | ASIL (6 matches) |
← 2020–21 2022–23 → | |
The 2021–22 Cypriot Second Division is the 67th season of the Cypriot second-level football league. The campaign started on the 10th of September 2021 and concluded on the 14th of May 2022.