2016 US Open – Mixed doubles
| Mixed doubles | |
|---|---|
| 2016 US Open | |
| Champions | Laura Siegemund Mate Pavić |
| Runners-up | CoCo Vandeweghe Rajeev Ram |
| Score | 6–4, 6–4 |
| Draw | 32 |
| Seeds | 8 |
Laura Siegemund and Mate Pavić won the title, defeating Vandeweghe and Ram in the final, 6–4, 6–4.
Martina Hingis and Leander Paes were the defending champions, but lost in the second round to CoCo Vandeweghe and Rajeev Ram.