2012 U.S. Men's Clay Court Championships – Singles
| Singles | |
|---|---|
| 2012 U.S. Men's Clay Court Championships | |
| 2011 Champion | Ryan Sweeting |
| Champion | Juan Mónaco |
| Runner-up | John Isner |
| Score | 6–2, 3–6, 6–3 |
| Draw | 28 |
| Seeds | 8 |
Ryan Sweeting was the defending champion but lost to John Isner in the quarterfinals. Isner lost in the final to Juan Mónaco, 2–6, 6–3, 3–6.